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	peripartum cardiomyopathy

Disease ID	1038
Disease	peripartum cardiomyopathy
Definition	Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration in cardiac function presenting typically between the last month of pregnancy and up to six months postpartum. As with other forms of dilated cardiomyopathy, PPCM involves systolic dysfunction of the heart with a decrease of the left ventricular ejection fraction (EF) with associated congestive heart failure and an increased risk of atrial and ventricular arrhythmias, thromboembolism (blockage of a blood vessel by a blood clot), and even sudden cardiac death. In essence, the heart muscle cannot contract forcefully enough to pump adequate amounts of blood for the needs of the body's vital organs.[1][2][3][4][5] - Wikipedia Reference: https://en.wikipedia.org/wiki/peripartum cardiomyopathy
Synonym	cardiomyopathy peripartum dilated cardiomyopathy secondary to peripartum heart disease dilated cardiomyopathy secondary to peripartum heart disease (disorder)
Orphanet	ORPHANET:563
DOID	DOID:9997
ICD10	ICD10CM:O90.3
UMLS	C0877208
SNOMED-CT	SNOMEDCT_US_2016_09_01:16253001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:13) C0018801 \| heart failure \| 4 C0878544 \| cardiomyopathy \| 4 C0032914 \| preeclampsia \| 2 C1960469 \| left ventricular noncompaction \| 2 C0035229 \| respiratory insufficiency \| 1 C0007785 \| cerebral infarct \| 1 C0018801 \| cardiac failure \| 1 C0007785 \| cerebral infarcts \| 1 C0003873 \| rheumatoid arthritis \| 1 C0003864 \| arthritis \| 1 C0018213 \| graves' disease \| 1 C0087086 \| thrombi \| 1 C0040053 \| thrombosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:34) 27032 \| ATP2C1 \| 1.197 \| DISEASES 9531 \| BAG3 \| 1.822 \| DISEASES 665 \| BNIP3L \| 2.151 \| DISEASES 29126 \| CD274 \| 2.323 \| DISEASES 959 \| CD40LG \| 1.526 \| DISEASES 1003 \| CDH5 \| 1.044 \| DISEASES 355 \| FAS \| 2.471 \| DISEASES 11245 \| GPR176 \| 2.371 \| DISEASES 3030 \| HADHA \| 3.362 \| DISEASES 3043 \| HBB \| 1.31 \| DISEASES 3045 \| HBD \| 2.323 \| DISEASES 3167 \| HMX2 \| 2.7 \| DISEASES 3360 \| HTR4 \| 1.48 \| DISEASES 3654 \| IRAK1 \| 1.47 \| DISEASES 3980 \| LIG3 \| 1.528 \| DISEASES 4607 \| MYBPC3 \| 1.465 \| DISEASES 4624 \| MYH6 \| 1.531 \| DISEASES 4625 \| MYH7 \| 2.384 \| DISEASES 4878 \| NPPA \| 1.963 \| DISEASES 4879 \| NPPB \| 2.581 \| DISEASES 5133 \| PDCD1 \| 2.551 \| DISEASES 5228 \| PGF \| 1.51 \| DISEASES 5618 \| PRLR \| 1.479 \| DISEASES 5664 \| PSEN2 \| 1.003 \| DISEASES 6019 \| RLN2 \| 5.022 \| DISEASES 6181 \| RPLP2 \| 2.463 \| DISEASES 84816 \| RTN4IP1 \| 3.267 \| DISEASES 6776 \| STAT5A \| 1.506 \| DISEASES 7137 \| TNNI3 \| 1.487 \| DISEASES 7139 \| TNNT2 \| 1.778 \| DISEASES 83696 \| TRAPPC9 \| 2.704 \| DISEASES 7273 \| TTN \| 2.148 \| DISEASES 51366 \| UBR5 \| 1.804 \| DISEASES 7422 \| VEGFA \| 1.041 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1038
Disease	peripartum cardiomyopathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0001635 \| Congestive heart failure \| 5 HP:0001638 \| Cardiomyopathy \| 4 HP:0006573 \| Acute fatty liver \| 2 HP:0030682 \| Left ventricular noncompaction \| 2 HP:0100602 \| Pre-eclampsia \| 2 HP:0001649 \| Tachycardia \| 2 HP:0001397 \| Hepatic steatosis \| 2 HP:0030149 \| Cardiovascular shock \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0100758 \| Gangrene \| 1 HP:0001663 \| Ventricular fibrillation \| 1 HP:0001279 \| Syncope \| 1 HP:0012173 \| Postural tachycardia \| 1 HP:0001369 \| Arthritis \| 1 HP:0002093 \| progressive respiratory failure \| 1 HP:0001644 \| Congestive cardiomyopathy \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0004756 \| Ventricular tachycardia \| 1

Disease ID	1038
Disease	peripartum cardiomyopathy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:14) C2707305 \| shortness of breath C2364133 \| infection C1962971 \| myocarditis C1299624 \| postural tachycardia syndrome C0948600 \| organ failure C0587044 \| left ventricular thrombus C0271240 \| unilateral blindness C0087086 \| thrombi C0022116 \| ischemia C0018802 \| congestive heart failure C0018801 \| cardiac failure C0017086 \| gangrene C0014378 \| enterovirus infection C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0087086 \| thrombi \| 1 C0018801 \| cardiac failure \| 1 C0017086 \| gangrene \| 1 C1299624 \| postural tachycardia syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:11)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
6	132908879	rs4458717	T	C	rs4458717	21665988	2.64E-11	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
6	139094355	rs2273509	T	C	rs2273509	21665988	1.84E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
11	49401125	rs7102702	T	G	rs7102702	21665988	1.35E-07	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
12	28017522	rs258415	A	C	rs258415	21665988	7.92E-19	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	71884567	rs12880291	G	T	rs12880291	21665988	2.39E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	71909854	rs12881957	C	T	rs12881957	21665988	1.85E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	71997723	rs17178387	A	G	rs17178387	21665988	2.38E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	72016613	rs7152674	G	T	rs7152674	21665988	2.80E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	72057355	rs11848785	G	A	rs11848785	21665988	2.40E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
14	72059551	rs3784064	G	A	rs3784064	21665988	2.79E-04	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't
15	86085776	rs2169876	T	C	rs2169876	21665988	2.35E-14	NA	NA	NA	41 healthy females; 703 female European ancestry controls	NOPOP(41)	European(703)	ALL(744)	NOPOP(41)	EUR(703)	ALL(744)	Peripartum cardiomyopathy	HPOID:0001638	Cardiomyopathy	DOID:9997	peripartum cardiomyopathy	D002311	Cardiomyopathy, Dilated	NA	NA	Heart disease	NA	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1038
Disease	peripartum cardiomyopathy
Case	(Waiting for update.)

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